Busulfan-inosimudzira Lung Damage: Zvese zvaunoda Kuti Uzive Nezve Rare Zvirwere Mudenga Iro Pink

Mazita Akanakisa Evana

Pasi:

Zuva Rekuzvarwa:

Tumira

Nditumire Neemail Ratidza Pane Saiti

Just In

• 6 hrs apfuura Chaitra Navratri 2021: Zuva, Muhurta, Tsika Uye Kukosha Kwemutambo uyu
• 
• 7 hrs apfuura Hina Khan Anobwinya Kumusoro Nemhangura Green Girazi Shadow Uye Glossy Nude Miromo Tora Iko Kutarisa Mune Mashoma Akareruka Matanho!
• 9 hrs apfuura Ugadi Uye Baisakhi 2021: Spruce Up Yako Festive Tarisa NaCelebs-Akafuridzirwa echinyakare Masutu
• 12 hrs apfuura Mazuva ese Horoscope: 13 Kubvumbi 2021

Usapotsa

• Sravana Sameeralu Serial 4th Technology BSNL Inobvisa Kuisirwa Mitero Kubva Kure Yakareba Broadband Kubatana
• Mitambo IPL 2021: BalleBaazi.com inogamuchira mwaka nemushandirapamwe mutsva 'Cricket Machao'
• Mafirimu Vira Sathidar Aka Narayan Kamble Kubva Kudare Anopfuura Nekuda Kwe COVID-19
• Nhau Varedzi vatatu vakatya kufa sezvo ngarava yabonderana nechikepe kubva kumahombekombe eMangaluru
• Mota Kabira Inofamba Hermes 75 Yakakwira-Yekumusoro Kwezvekutengesa Kuendesa Magetsi Scooter Yakatangwa MuIndia
• Zvemari Goridhe Mutengo Unowira Kwete Zvakawanda Kushushikana kweNBFCs, Mabhangi Anoda Kuva Akarinda
• Dzidzo CSBC Bihar Mapurisa Constable Yekupedzisira Mhedzisiro 2021 Yakaziviswa
• Kufamba 10 Nzvimbo Dzakanakisa dzekushanyira Mu Maharashtra Muna Kubvumbi

Iyo nyowani Bollywood firimu 'Sky Is Pink' iri munhau nekuda kwezvakanaka zvikonzero. Kubva pane iyo chaiyo-yehupenyu nyaya yaAisha Chaudhary, iyo bhaisikopo inotenderera neyakajairika mamiriro ekurapa, Busulfan-inokonzeresa kukuvara kwemapapu kana pulmonary fibrosis iyo yakakonzera kufa kusingatarisirwe kwaAisha pazera diki re18.

Akazvarwa aine hutachiona hwakakomba pamwe chete (SCID), musikana mudiki aifanirwa kuzoiswa marora mumwedzi mitanhatu yekuzvarwa, paakaiswa paBusulfan (mushonga wekenza). Mushonga uyu wakazoenderera mberi uchikonzera pulmonary fibrosis inova isingawanzoitika mhedzisiro yemushonga.

Tisati tapinda mukunzwisisa izvo Busulfan-inokonzeresa kukuvara kwemapapu uye nezvayo, ngatitarisei SCID.

Chii chakakomba chakabatanidzwa Immunodeficiency (SCID)?

Iyo isingawanzoitika geni kusagadzikana, SCID inoratidzirwa nekukanganisa kukura kweanoshanda T masero uye B maseru, semhedzisiro yeakawanda magene ekuchinja. Mamiriro acho anokonzeresa mwana kudzikira zvakanyanya kana kusava nechengetedzo zvachose, zvichikonzera kuti muviri wemwana ugare wakanangana nemarudzi akasiyana ezvirwere ^{[1] [piri]} .

Vana vane ichi chisingawanzo, chirwere chakagarwa nhaka vanorwara zvakanyanya nezvirwere zvakaita semabayo, meningitis, uye chickenpox uye vanogona kufa mukati megore rekutanga rehupenyu hwavo. Zvisinei, mishonga yemazuva ano uye nzira dzokurapa dzakabatsira kuvandudzwa.

Bone marrow transplant ndiyo inonyanya kurapa SCID ^[3] .

Saka, Chii Chinonzi Bone Marrow Kuisa?

Kuiswa kwemongo wemapfupa kurapwa kunotsiva mwongo usina hutano uine hutano. Bone marora ndiyo yakapfava, inonamira mukati memapfupa ako inogadzira maseru-anoita masero (maseru eropa) anoshanduka kuita masero eropa kurwisa hutachiona, anotakura okisijeni mumuviri wese nekudzivirira kubuda ropa. ^[4] .

Kuisirwa kunoitiswa kupinza maseru emongo emapfupa mune munhu mushure mekunge mwongo wavo usina hutano wabviswa, uye zvinobatsira mukuvandudza immune system yemwana ^[5] .

Pamwe pamwe nezvizhinji zvezvibereko zvinoiswa zvine chekuita nekuvandudza hutano hweumwe munhu, zvakare zvine matambudziko akati wandei sekubatana-kurwisa-kuitisa chirwere, stem cell kutadza, kukuvara kwemitezo, hutachiona, chirwere chemaziso, kushaya mbereko, kanzira nyowani uye nyangwe kufa. ^{[6] [1]} .

Busulfan inorwisa-kenza chemotherapy mushonga uyo unoshandiswa mune yemapfupa ekuchinjisa maitiro. Nekudaro, kwave nemishumo yemushonga une chinokanganisa vanhu avo vakamboiswa, ne pulmonary fibrosis ndiyo yakanyanya kuomarara.

Zvino zvatave kufukidza nzvimbo, ngatitarisei pamusoro wepakati, 'Busulfan-indased mapapu kukuvara' uye kune izvo, isu tinofanirwa kuziva kuti chii Busulfan uye kuti inoshanda sei ^[7] .

Chii chinonzi Busulfan?

Iwo mushonga wekurapa unoshandiswa kurapa kanzira uye kuparadza isingadiwe mongo wemapfupa pamberi pekupfupa kwemongo. Iyo chemotherapy mushonga ndeyeboka remishonga inonzi alkylating agents uye inoshanda nekudzikamisa kana kumisa kukura kwemasero ekenza mumuviri wako. ^[8] . Iyo inoshandiswawo pakurapa kumwe kusagadzikana kweropa senge polycythemia vera uye myeloid metaplasia uye kurapa chisingaperi myelogenous leukemia (CML) ^[9] .

Nekudaro, iyo chemotherapy mushonga, sezvambotaurwa ine muguva divi mhedzisiro iyo inokonzeresa pulmonary fibrosis iyo inonzi seBusulfan-inokonzerwa nemapapu kukuvara. ^{[9] [10]} .

Chii chinonzi Busulfan Lung Damage?

Busulfan mapapu, kiriniki inonzi pulmonary fibrosis inokonzerwa nemushonga umo nyama yemapapu inokuvara uye kupiswa. Kunyangwe isingawanzoitika, mamiriro acho anouraya uye anoitika mune asingasviki mashanu muzana evarwere vakabatwa naBusulfan ^{[gumi neimwe]} . Chirevo chekutanga chekukuvara kwemapapu kweBusulfan chakataurwa muna 1961.

Mamiriro acho anoita kuti shinda dzakaoma uye dzakaomarara dziumbwe mumapapu, izvo zvinoita kuti zviomere munhu kufema.

Asi, zvinofanirwa kucherechedzwa kuti mushonga une zvimwe zvakakomba mhedzisiro, seinotevera ^[12] :

• Haemorrhages
• Kushaya simba
• Cataract
• Testicular atrophy
• Amenorrhoea
• Kukanganiswa kwemucheche
• Kuchengeta
• Pulmonary fibrosis
• Kuiswa kweuric acid muitsvo tubules
• Anemia
• Alopecia
• Gynaecomastia

Mimwe mhedzisiro yakaoma yemushonga ndeinotevera ^{[gumi neimwe]} :

• Kuonda
• Nausea
• Hyperpigmentation yeganda
• Kusvipa
• Manyoka
• Rashes
• Kuneta
• Muromo wakaoma

Busulfan Lung Damage Inoonekwa Sei?

Tichifunga nezvekuti mamiriro acho anokonzerwa nemushonga, zvinonetsa kuongorora mamiriro acho. Uye muzviitiko zvakawanda, mamiriro acho anenge ari mudanho repamberi.

Yakakwira-resolution computed tomography (CT Scan) uye histopathology ndiyo nzira dzepedyo dzinogona kubatsira kuongorora mamiriro acho ^[13] . Mune zvimwe zviitiko zvekukuvara kwemapapu kweBusulfan, kuongororwa kwakaratidza zvinotevera:

• Yakaderedzwa kabhoni monoxide (CO) kuburitsa kugona
• Kudzivirira kufema maitiro pane pulmonary basa kuyedza
• X-ray yechipfuva inogona kuratidza mavara asina kujairika uye mativi kumativi ese emapapu
• Kuvapo kwematare
• Ruvara rwebhuruu rwemiromo, ganda, kana nzara nekuda kweakaderera eropa oxygen mazinga
• Kuwedzera zvisina kujairika kwechigadziko cheminwe

Pane Yekupedzisira Chiziviso ...

Kana mamiriro acho akabatwa mumatanho ekutanga, zviri nyore kupomhodza mushonga-unokonzeresa pulmonary fibrosis - sekurapwa kwazvino kwezvinodhaka uye mushonga mutsva ungatangwa. ^{[14] [gumi neshanu]} .

Nekudaro, zvimwe zvidzidzo zvinofanirwa kuitiswa pakunzwisisa mafambiro eanouraya mishonga-inosimudzira mamiriro uye kukudziridza inoshanda kurapwa kurapwa kune imwecheteyo.

1. [1]De Ravin, S. S., Wu, X., Moir, S., Kardava, L., Anaya-O'Brien, S., Kwatemaa, N., ... & Marquesen, M. (2016). Lentiviral hematopoietic stem cell gene kurapa kweX-yakabatana yakaoma yakasanganiswa immunodeficiency. Sayenzi yekududzira mushonga, 8 (335), 335ra57-335ra57.
2. [piri]Palacios, T. V., Vergales, B., Wisniewski, J., Borish, L., & Lawrence, M. G. (2016). Yunivhesiti yeVirginia inosangana nekushandisa kuongororwa kwevana vachangoberekwa kwehutachiona hwakabatana pamwe chete (SCID). Zvinyorwa zveAllergy uye Clinical Immunology, 137 (2), AB216.
3. [3]Sundin, M., Marits, P., Ramme, K., Kolios, A. G., & Nilsson, J. (2019). Yakakomba yakasanganiswa immunodeficiency (SCID) inoratidzira muhudiki, ine agammaglobulinemia, inosanganisirwa nerinovhenganiswa remubatanidzwa heterozygous mutations muDCLRE1C. Clinical Immunology, 200, 16-18.
4. [4]Klein, O. R., Buddenbaum, J., Tucker, N., Chen, A. R., Gamper, C. J., Loeb, D., ... & Holuba, M. J. (2017). Nonmyeloablative haploidentical bone marrow kuisirwa ne post-transplantation cyclophosphamide yevana uye vechidiki varwere vakuru vane njodzi huru yehematologic malignancies. Biology YeRopa uye Marrow Kuisazve, 23 (2), 325-332.
5. [5]Robinson, T. M., O'Donnell, P. V., Fuchs, E. J., & Luznik, L. (2016, Kubvumbi). Haploidentical bone marora uye stem cell transplantation: ruzivo ne post-transplantation cyclophosphamide. Mumisangano muhematology (Vol. 53, Nha. 2, mapeji 90-97). WB Saunders.
6. [6]Morishima, Y., Kashiwase, K., Matsuo, K., Azuma, F., Morishima, S., Onizuka, M., ... & Mori, T. (2015). Biological kukosha kweHLA locus inoenderana mune isina hukama mupi wemafuta ekutsvaira. Ropa, 125 (7), 1189-1197.
7. [7]Ikeda, J., Scipione, C., Hyduk, S., Althagafi, M. G., Gao, X., Jongstra-Bilen, J., & Cybulsky, M. I. (2019). Bone Marrow Kudyara Kunokanganisa Kwekutanga Chikamu cheAtherosclerotic Lesion Kuumbwa. Arteriosclerosis, Thrombosis, uye Vascular Biology, 39 (Suppl_1), A534-A534.
8. [8]Bezinelli, L. M., Eduardo, F. P., De Carvalho, D. L. C., dos Santos Ferreira, C. E., De Almeida, E. V., Sanches, L. R., ... & Corrêa, L. (2017). Therapeutic salivary monitoring of IV busulfan in patients underhematopoietic stem cell transplantation: chidzidzo chekutyaira. Bone marora kuisazve, 52 (10), 1384.
9. [9]Tutschka, P. J., Copelan, E. A., & Klein, J. P. (1987). Bone marrow kuisirwa kweleukemia inotevera bhusulfan nyowani uye cyclophosphamide regimen. Ropa, 70 (5), 1382-1388.
10. [10]Jain, R., Gupta, K., Bhatia, A., Bansal, A., & Bansal, D. (2017). Hepatic sinusoidal-obstruction syndrome uye busulfan-inokonzeresa kukuvara kwemapapu mune yekupedzisira-autologous stem sero yekuisa mugashiri. Indian vanachiremba vevana, 54 (9), 765-770.
11. [gumi neimwe]Matijasic, N., Bonevski, A., Tokic Pivac, V., & Pavic, I. (2019). Busulfan-Inokonzeresa Lung Kukuvara muPediatric Oncology Varwere-Ongororo yeiyo Mabhuku neChiitiko Chinoratidza. Chiremba Allergy, Immunology, uye Pulmonology, 32 (3), 86-91.
12. [12]Mourad, M., & Crosser, M. S. (2016). A48 DZIDZO YEMAHARA YEMAHARA YAKABATANIDZWA CHIRWERE CHEMAFUNGWA: Pulmonary Inopinda Inoteverwa nePeripheral Stem Cell Transplantation, Haisi Pneumonia Inotapukira Nguva Dzose. Nyaya Yebusulfan-Yakakonzera Pulmonary Kukuvara. American Zvinyorwa zveKufema uye Kwakakomba Kuchengeta Mushonga, 193, 1.
13. [13]Rix, A., Drude, N., Mrugalla, A., Baskaya, F., Pak, K. Y., Grey, B., ... & Mottaghy, F. M. (2019). Kuongorora kweChemotherapy-Yakakonzera Kuipa Kwepanyama neGa-68 Yakanyorwa Duramycin. Molecular Kufungidzira uye Biology, 1-11.
14. [14]Themanns, M., Koban, F., Bergmayr, C., Chrzan, A., Strohmaier, W., Haybaeck, J., ... & Zebedin-Brandl, E. (2019). Treprostinil inoderedza endothelial kukuvara mumurine sinusoidal obstruction syndrome. Zvinyorwa zveMorecular Medicine, 97 (2), 201-213.
15. [gumi neshanu]Averyanov, A., Kogan, E., & Lesnyak, V. (2020). Zvinodhaka zvinokonzerwa nezvinodhaka. Mune Zvakaoma Kuziva Rare Inoparadzanisa Chirwere Chemapapu (map. 393-408). Dzidzo Press.

Horoscope Yako Yemangwana

Kuziva

Nditumire Neemail Ratidza Pane Saiti